Journal
MITOCHONDRION
Volume 19, Issue -, Pages 191-197Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.mito.2014.04.005
Keywords
Plant mitochondria; RNA editing; PPR proteins; Protein-RNA code; MORF proteins
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Funding
- Deutsche Forschungsgemeinschaft [TA624/4-1, TA624/6-1, TA624/2-2, BR726/9-5, BR726/11-1]
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RNA editing changes several hundred cytidines to uridines in the mRNAs of mitochondria in flowering plants. The target cytidines are identified by a subtype of PPR proteins characterized by tandem modules which each binds with a specific upstream nucleotide. Recent progress in correlating repeat structures with nucleotide identities allows to predict and identify target sites in mitochondrial RNAs. Additional proteins have been found to play a role in RNA editing; their precise function still needs to be elucidated. The enzymatic activity performing the C to U reaction may reside in the C-terminal DYW extensions of the PPR proteins; however, this still needs to be proven. Here we update recent progress in understanding RNA editing in flowering plant mitochondria. (C) 2014 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
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