Journal
MITOCHONDRION
Volume 19, Issue -, Pages 357-364Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.mito.2014.01.001
Keywords
Glycine decarboxylase; Non-coupled electron transport; Ma late dehydrogenase; Carbonic anhydrase; Photorespiration
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Funding
- National Science and Engineering Research Council of Canada
- Agriculture and Agri-Food Canada
- Swedish Research Council
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Oxidation of glycine in photorespiratory pathway is the major flux through mitochondria of C3 plants in the light. It sustains increased intramitochondrial concentrations of NADH and NADPH, which are required to engage the internal rotenone-insensitive NAD(P)H dehydrogenases and the alternative oxidase. We discuss here possible mechanisms of high photorespiratory flux maintenance in mitochondria and suggest that it is fulfilled under conditions where the concentrations of glycine decarboxylase reaction products NADH and CO2 achieve an equilibrium provided by malate dehydrogenase and carbonic anhydrase, respectively. This results in the removal of these products from the glycine decarboxylase multienzyme active sites and in the maintenance of their concentrations at levels sufficiently low to prevent substrate inhibition of the reaction. (C) 2014 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
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