Journal
MITOCHONDRION
Volume 13, Issue 2, Pages 134-142Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.mito.2013.01.006
Keywords
Mitochondrial biogenesis; PGC-1 alpha; Caloric restriction; Reactive oxygen species; Hypoxia
Categories
Funding
- Emmy-Noether-Program of the Deutsche Forschungsgemeinschaft
- Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD)
- [SFB 635]
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Cell function relies on the constant supply of ATP and it is crucial that mitochondrial ATP production adapts to environmental and cellular challenges to maintain cellular function. Key molecules in sensing cellular stress situations seem to be the PGC-family of transcriptional co-activators, which are key regulators of mitochondrial biogenesis. Recent work has identified several stress-regulated pathways that affect mitochondrial biogenesis through modulation of the activity of PGC-1 alpha. This review focuses on caloric restriction, hypoxia as well as the role of reactive oxygen species in regulating mitochondrial biogenesis and how this process is linked to other cellular stress responses. (C) 2013 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
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