Journal
MITOCHONDRION
Volume 13, Issue 6, Pages 676-680Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.mito.2013.09.007
Keywords
MELAS; Stroke-like episodes; MRI; Arterial spin labeling; Perfusion imaging
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Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- Japan Society for the Promotion of Science [23790985, 25461311]
- Research on Intractable Diseases (Mitochondrial Disorder) from the Ministry of Health, Labour and Welfare of Japan
- Grants-in-Aid for Scientific Research [24111517, 23790985, 25461311] Funding Source: KAKEN
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In stroke-like episodes (SEs) of patients with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS), the detection of preclinically latent lesions is a challenge. We report regional cerebral hyperperfusion observed on arterial spin labeling (ASL) perfusion magnetic resonance imaging (MRI) in the preclinical phase more than 3 months before the clinical onset of SEs in 3 MELAS patients. These hyperperfused areas were not detected by conventional MRI in the preclinical phase and developed into acute lesions at the clinical onset of SEs, suggesting that ASL imaging has the potential for predicting the emergence of SEs. (C) 2013 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
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