Journal
MITOCHONDRION
Volume 13, Issue 3, Pages 225-234Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.mito.2012.06.003
Keywords
Cardiac glycosides; Sodium/potassium-ATPase; Apoptosis; Autophagy; Cell cycle; Mcl-1
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Funding
- Waxweiler grant for cancer prevention research from the Action LIONS Vaincre le Cancer
- Recherche Cancer et Sang Foundation
- Recherches Scientifiques Luxembourg Association
- Een Haerz fir kriibskrank Kanner Association
- Action Lions Vaincre le Cancer Association
- Televie Luxembourg
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Cardiac glycosides (CGs) are compounds used for the treatment of cardiac failure which also display strong anti-cancer activity inducing impairment of cell proliferation or activation of cell death whether by apoptosis or autophagy. Despite the fact that the sodium/potassium (Na+/K+)-ATPase is a well-known target of CGs, its involvement in the anti-cancer effect of these compounds remains to be validated. Importantly, related intra-cellular sensor(s)/transducer(s) needs further characterization. We will discuss here key mechanisms activated by CGs including their ability to modulate the cell cycle and to regulate the expression of anti-apoptotic Bcl-2 family members, two so far marginally investigated events. (C) 2012 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
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