Journal
MITOCHONDRION
Volume 12, Issue 1, Pages 66-76Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.mito.2011.07.003
Keywords
Mitochondria; Sirtuins; Toxicology; Oxidative stress; Metabolism
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Funding
- Portuguese Foundation for Science and Technology (FCT) [PTDC/SAU-TOX/110952/2009]
- FCT [SFRH/BD/48029/2008]
- Polish Ministry of Science and Higher Education [NN407 075 137]
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The link between sirtuin activity and mitochondrial biology has recently emerged as an important field. This conserved family of NAD(+)-dependent deacetylase proteins has been described to be particularly involved in metabolism and longevity. Recent studies on protein acetylation have uncovered a high number of acetylated mitochondrial proteins indicating that acetylation/deacetylation processes may be important not only for the regulation of mitochondrial homeostasis but also for metabolic dysfunction in the context of various diseases such as metabolic syndrome/diabetes and cancer. The functional involvement of sirtuins as sensors of the redox/nutritional state of mitochondria and their role in mitochondrial protection against stress are hereby described, suggesting that pharmacological manipulation of sirtuins is a viable strategy against several pathologies. (C) 2011 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
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