Journal
MITOCHONDRION
Volume 12, Issue 4, Pages 459-464Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.mito.2012.06.005
Keywords
Mitochondrial bioenergetics; Reactive oxygen species; mtDNA copy number
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Funding
- University of New South Wales
- ARC [DP110104542]
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The influence of mitochondrial DNA (mtDNA) mutations on human disease has been extensively studied, but the impact of mutations within the adaptive range is debated. We studied males from lines of Drosophila melanogaster that have a highly standardized nuclear genome but different mtDNA, at two ages. We measured mitochondrial respiration on permeabilized muscle fibers, hydrogen peroxide production of isolated mitochondria and mtDNA copy number of whole individuals. The results show that a small set of naturally occurring mtDNA mutations can have a significant influence on mitochondrial bioenergetics that may change as the organism ages. (C) 2012 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
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