Journal
MITOCHONDRION
Volume 12, Issue 4, Pages 438-440Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.mito.2012.05.003
Keywords
mtDNA; Mitochondria; Bovine
Categories
Funding
- Wellcome Trust Centre for Mitochondrial Research [WT096919Z/11/Z]
- Medical Research Council (UK) Translational Neuromuscular Centre
- UK NIHR Biomedical Research Centre for Ageing and Age-related Disease
- Medical Research Council [G0800470] Funding Source: researchfish
- MRC [G0800470] Funding Source: UKRI
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The Chillingham herd of wild Northumbrian cattle remains viable despite over 300 years of in-breeding and a near-homozygous nuclear genome. Here we report the complete mitochondrial DNA sequence using ultra-deep next generation sequencing. Random population sampling of similar to 10% of the extant herd identified a single mtDNA haplotype harbouring a unique bovine variant present in all other higher mammals (m.11789C/Y421H) which may contribute to their survival. (C) 2012 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
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