Journal
MITOCHONDRION
Volume 11, Issue 3, Pages 457-466Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.mito.2011.01.008
Keywords
Granulocyte-colony stimulating factor; Mitochondria; Heart; Oxidative stress; Membrane potential; Ischemia
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Funding
- Thailand Research Fund [RTA 5280006, RMU 5180007]
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During cardiac ischemia-reperfusion injury, reactive oxygen species (ROS) level is markedly increased, leading to oxidative stress and mitochondrial dysfunction. Although granulocyte-colony stimulating factor (G-CSF) is known to be cardioprotective, its effects on cardiac mitochondria during oxidative stress have never been investigated. In this study, we discovered that G-CSF completely prevented mitochondrial swelling and depolarization, and markedly reduced ROS production caused by H2O2-induced oxidative stress in isolated cardiac mitochondria. Its effects were similar to those treated with cyclosporine A and 4'-chlorodiazepam. These findings suggest that G-CSF could act directly on cardiac mitochondria to prevent mitochondrial dysfunction caused by oxidative stress. (C) 2011 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
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