Journal
MITOCHONDRION
Volume 11, Issue 3, Pages 504-512Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.mito.2011.01.009
Keywords
Chronic periodontitis; Mitochondria; mtDNA; Mutations; ROS
Categories
Funding
- Department of Biotechnology (DBT), Government of India
Ask authors/readers for more resources
We performed an extensive study on mitochondrial dysfunction in chronic periodontitis (CP). Electron microscopic analysis of gingival cells revealed abnormal mitochondria in 60% of the patients. Mitochondrial membrane potential and oxygen consumption of gingival cells were reduced by 4 fold and 5.8 fold, respectively; whereas ROS production was increased by 18%. The genetic analysis by complete mitochondrial DNA sequencing revealed the identification of 14 novel mutations only in periodontal tissues but not in the blood, suggesting a role of oxidative stress on periodontal tissues. Thus, our functional and genetic analysis provided an evidence for the mitochondrial dysfunction in CP. (C) 2011 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available