Journal
MITOCHONDRION
Volume 10, Issue 5, Pages 411-418Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.mito.2010.05.014
Keywords
Mitochondria; Neurodegeneration; Neuroinflammation; Reactive oxygen species; MS; EAE
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Dysfunctional mitochondria are thought to play a cardinal role in the pathogenesis of various neurological disorders, such as multiple sclerosis, Alzheimer's disease, Parkinson's disease and stroke. In addition, neuroinflammation is a common denominator of these diseases. Both mitochondria' dysfunction and neuroinflammatory processes lead to increased production of reactive oxygen species (ROS) which are detrimental to neurons. Therefore, neuroinflammation is increasingly recognized to contribute to processes underlying neurodegeneration. Here we describe the involvement of mitochondria' (dys)function in various neurological disorders and discuss the putative link between mitochondrial function and neuroinflammation. (C) 2010 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
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