Journal
MITOCHONDRION
Volume 10, Issue 3, Pages 243-252Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.mito.2009.12.143
Keywords
Cancer; Warburg effect; Metabolic reprogramming; Uncoupling protein-2; Oxidative stress; Chemoresistance
Categories
Ask authors/readers for more resources
Cancer cells respond to unfavorable microenvironments such as nutrient limitation, hypoxia, oxidative stress, and host defense by comprehensive metabolic reprogramming. Mitochondria are linked to this complex adaptive response and emerging evidence indicates that uncoupling protein-2 (UCP2), a mitochondria' inner membrane anion carrier, may contribute to this process. Effects of UCP2 on mitochondrial bioenergetics, redox homeostasis, and oxidant production in cancer cells may modulate molecular pathways of macromolecular biosynthesis, antioxidant defense, apoptosis, cell growth and proliferation, enhancing robustness and promoting chemoresistance. Elucidation of these interactions may identify novel anti-cancer strategies. Published by Elsevier B.V. on behalf of Mitochondria Research Society.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available