Journal
MINI-REVIEWS IN ORGANIC CHEMISTRY
Volume 8, Issue 1, Pages 38-48Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/157019311793979891
Keywords
Gene Therapy; DNA; Liposomes; Complexes; Metal ions; X-ray
Categories
Funding
- Polytechnic University of Marche (Italy)
- Ministry of Education, University and Science (Rome, Italy)
- University Spin-off BINT
- Polytechnic University of Marche
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Among the synthetic vectors exploitable in Human Gene Therapy (HGT), complexes of DNA with cationic liposomes (lipoplexes) are considered the best candidates. Some degree of cytotoxicity and a limited stability on serum are still limiting factors for applications in vivo. On the contrary the corresponding complexes of neutral liposomes are enough stable and non toxic. This review has the aim to offer a survey of existing data, namely structural properties, on neutral liposomes from the point of view of HGT; and to compare, whenever possible, the different features of the two classes of compounds. The outlook is that in near future neutral liposomes could behave as efficient and safe vectors of genetic material.
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