Journal
MINI-REVIEWS IN ORGANIC CHEMISTRY
Volume 6, Issue 1, Pages 35-43Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/157019309787316111
Keywords
Fluorescein; fluorescent probe; fluorescent dye; fluorescence spectroscopy
Categories
Funding
- NSFC [20572129]
- National Key Project for Basic Research [2003CB114405]
- USDA
- China Scholarship Council
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After its first synthesis in 1871, fluorescein and its derivatives have been used as a powerful tool for molecular and cellular studies in biology, molecular biology, interactions between ligands and macromolecules, for drug discovery and environmental research. In recent 20 years, research attention has been paid particularly to synthesis and separation of fluorescein derivatives having various linker groups. This mini-review briefly summarizes synthesis of fluorescein derivatives for improving their chemical, fluorescent and biological properties and conjugation suitability.
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