Journal
MINI-REVIEWS IN ORGANIC CHEMISTRY
Volume 5, Issue 4, Pages 274-286Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/157019308786242142
Keywords
Cyclopeptide; glycocluster; multivalency; carbohydrate; solid-phase synthesis; oxime ligation
Categories
Funding
- Association pour la Recherche contre le Cancer ( ARC)
- Centre National pour la Recherche Scientifique (CNRS)
- Universite Joseph Fourier (UJF)
- COST [D34]
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Many important biological processes including fertilization, tissue formation, cell adhesion, antigen/antibody interactions, cancer metastasis or pathogen infection involve polyvalent interactions between oligomeric proteins and carbohydrate-based ligands. The synthesis of multitopic, molecularly-defined structures that display both clustered sugars and immobilization or bioactive agents represents an attractive approach for the discovery of new diagnostics and therapeutics. This mini-review updates the current developments in this field by focusing on the recent interests on cyclopeptide-based glycoclusters.
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