Journal
MINI-REVIEWS IN MEDICINAL CHEMISTRY
Volume 13, Issue 11, Pages 1607-1625Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389557511313110007
Keywords
Pyrazine; anti-tubercular agents; anticancer agents; diuretics; anti-diabetic agents
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Funding
- Sinhgad Technical education Society, Pune
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Pyrazine is one of the important class of heterocyclic compounds that can be obtained naturally or synthesized chemically. Pyrazine ring has got importance in exhibiting various biological activities in association with other scaffolds like pyrrole, pyrazole, imidazole, triazole, tetrazole, thiophene, oxazole, pyridine, piperidine and piperazine. Presence of pyrazine ring as a basic scaffold in various clinically used drugs exhibits its importance in drug design. In this review, attempt has been made to disclose various therapeutic applications of pyrazine derivatives reported during the last decade.
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