Journal
MINI-REVIEWS IN MEDICINAL CHEMISTRY
Volume 11, Issue 10, Pages 910-919Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138955711796575416
Keywords
ent-kaurane; diterpenoids; derivatives; anti-tumor activity; mechanism of action; structure-activity relationships
Categories
Funding
- National Natural Science Fund [30973610]
- Ministry of Education of China [108069]
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The ent-kaurane diterpenoids are widely distributed in China, some of which have high natural abundance in plants of Isodon, Pteris, Gnaphalium, Diplospora, Croton and some other species. These compounds exhibit significant anti-tumor, antibacterial and anti-inflammatory activities, which have attracted the attention of medicinal chemists. This review focuses on the recent advances in the research of derivatives, anti-tumor activity, mechanism of action, and structure-activity relationships of ent-kaurane diterpenoids. All of these will show the potential in the development of new antitumor agents in natural products.
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