Journal
MINI-REVIEWS IN MEDICINAL CHEMISTRY
Volume 11, Issue 13, Pages 1122-1129Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138955711797655362
Keywords
Berberine; structural modification; biological activities
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Funding
- National Natural Science Foundation of China [81072554]
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Berberine is an isoquinoline alkaloid isolated from Chinese herbs such as Coptidis Rhizome. This paper is a systematic review of the structural modifications of berberine for different biological activities such as antitumor, antimicrobial, anti-Alzheimer's disease, antihyperglycemic, anti-inflammatory and antimalaria. The current review would provide some useful information for further studies on structural modification of berberine for discovering new drug leads.
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