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Advances in Structural Modifications and Biological Activities of Berberine: An Active Compound in Traditional Chinese Medicine

Journal

MINI-REVIEWS IN MEDICINAL CHEMISTRY
Volume 11, Issue 13, Pages 1122-1129

Publisher

BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138955711797655362

Keywords

Berberine; structural modification; biological activities

Funding

  1. National Natural Science Foundation of China [81072554]

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Berberine is an isoquinoline alkaloid isolated from Chinese herbs such as Coptidis Rhizome. This paper is a systematic review of the structural modifications of berberine for different biological activities such as antitumor, antimicrobial, anti-Alzheimer's disease, antihyperglycemic, anti-inflammatory and antimalaria. The current review would provide some useful information for further studies on structural modification of berberine for discovering new drug leads.

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