Journal
MINI-REVIEWS IN MEDICINAL CHEMISTRY
Volume 9, Issue 9, Pages 1102-1112Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138955709788922656
Keywords
ATP binding cassette transporters; antitumor drugs; modulators
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Funding
- Associazione Italiana per la Ricerca sul Cancro, Milan
- Ministero della Salute, Rome
- Fondazione Italo Monzino, Milan
- EU [CHEMORES]
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ATP binding cassette transporters are implicated in multidrug resistant phenotypes of tumor cells and may be cancer stem cell markers. Inhibitors of drug efflux pumps represent an emerging group of potentially useful agents for the improvement of antitumor therapy. Here we provide an overview of drug transporter functions and modulation.
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