Roles of Laminin-332 and alpha 6 beta 4 Integrin in Tumor Progression

Laminin-332 and alpha 6 beta 4 integrin is major hemidesmosome components in the skin. As many studies have shown that laminin-332 and alpha 6 beta 4 integrin play important roles in tumor progression via activation of phosphatidylinositol-3 kinase signaling, understanding of the molecular mechanisms of them could lead to a new drug for cancer therapy.