Journal
MINI-REVIEWS IN MEDICINAL CHEMISTRY
Volume 9, Issue 2, Pages 186-193Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138955709787316065
Keywords
Molecular modeling; P-glycoprotein/ABCB1; MRP4/ABCC4; MRP5/ABCC5; multidrug resistance
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Funding
- Norwegian Cancer Society
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Multidrug resistance (MDR) is a limitation to cancer chemotherapy, antibiotic treatment and HIV medication. Molecular models of the ABC transporters ABCB1 (P-glycoprotein), ABCC4 (multidrug resistance protein 4 (MRP4)) and ABCC5 (MRP5), which are involved in MDR, may aid in the development of drugs inhibiting anticancer agents efflux.
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