Journal
MINI-REVIEWS IN MEDICINAL CHEMISTRY
Volume 8, Issue 7, Pages 719-727Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138955708784567449
Keywords
FAP; DPP4; dipeptidyl peptidase; prolyl peptidase; inhibitor; cancer
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Numerous studies implicate the prolyl peptidase, fibroblast activation protein (FAP) in tumorigenesis; however, FAP-selective inhibitors have not yet been developed to fully validate FAP as a therapeutic target. Herein, we review recent efforts aimed at validating and inhibiting FAP for cancer therapy and highlight future directions for successful targeting of this prolyl peptidase.
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