4.5 Review

Selenium compounds and apoptotic modulation:: A new perspective in cancer therapy

Journal

MINI-REVIEWS IN MEDICINAL CHEMISTRY
Volume 8, Issue 10, Pages 1020-1031

Publisher

BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138955708785740625

Keywords

selenium; cancer; cytotoxicity; apoptosis

Funding

  1. University of Navarra Research Plan

Ask authors/readers for more resources

Recent epidemiological studies have demonstrated that selenium may be an effective chemopreventive and anticancer agent with a broad spectrum against several human cancer cells (prostate, colon, bladder, lung, liver, ovarian, leukemia). A wide range of potential mechanisms have been proposed for the antitumorigenic effects of selenium and these include antiandrogen activity, growth inhibitory effects by regulation of p53 and antioxidant function, and through DNA damage. However, apoptosis is one of the most plausible mechanisms for the anticancer activity. The regulating mechanisms of apoptosis are extremely complex and for selenium compounds they mainly involve a mitochondrial pathway, protein kinases, tumor necrosis factor, activation of caspases and reactive oxygen species. The aim of this review is to summarize the current knowledge about more than twenty eight selenium-containing molecules and to discuss the implications for apoptosis and the impact in cancer therapy.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.5
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available