4.5 Review

Recent advances of dendrimers in delivery of genes and drugs

Journal

MINI-REVIEWS IN MEDICINAL CHEMISTRY
Volume 8, Issue 9, Pages 889-900

Publisher

BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138955708785132729

Keywords

dendrimer; delivery of dene; delivery of drug; DNA/RNA; PAMAM; PEI; PPI

Funding

  1. National Natural Science Foundation of China [30500197]

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Dendrimers as a new kind of polymer have been studied for medical applications mainly in two aspects: drug delivery and gene delivery. The unique characteristics, such as uniformity, monodispersity and the ability to functionalize their terminal groups with various targeting agents distinguish them as versatile carriers. In the paper the recent advances of dendrimer in gene transfer vehicles and drug delivery are separately reviewed. These advances illustrate the direction of the future development of dendrimers.

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