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Apoptotic Signaling Pathways as a Target for the Treatment of Liver Diseases

Journal

MINI-REVIEWS IN MEDICINAL CHEMISTRY
Volume 8, Issue 14, Pages 1485-1493

Publisher

BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138955708786786499

Keywords

Liver; hepatitis; alcohol; hepatocarcinoma; cholestasis; fulminant hepatic failure; steatohepatitis; fibrosis

Funding

  1. Instituto de Salud Carlos III
  2. Fondo de Investigacions Sanitarias

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Dysregulation of apoptosis is a major contributor to the initiation and aggravation of liver injury. Agents that modulate apoptosis may be of therapeutic benefit in a number of liver diseases, and research related to cell type-specific activation or inhibition of apoptotic signaling pathways will provide new strategies for treatment.

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