Journal
MINI-REVIEWS IN MEDICINAL CHEMISTRY
Volume 8, Issue 7, Pages 711-718Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138955708784567430
Keywords
pro-apoptotic cancer therapy; selective antitumour agents; apoptosis; small molecules; mitochondria-targeting; X-linked inhibitor of apoptosis (XIAP); B-cell lymphoma 2 (Bcl-2); aerobic glycolysis
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Resistance to apoptosis is one of the fundamental hallmarks of cancer. Recently, the selective induction of apoptosis in cancer cells has emerged as an exciting possibility for the development of future selective cancer therapy. This review will summarise the development of the major classes of small molecule pro-apoptotic antitumour agents.
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