Journal
MICROVASCULAR RESEARCH
Volume 82, Issue 1, Pages 92-95Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.mvr.2011.03.006
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Funding
- Arnold and Mabel Beckman Foundation
- National Science Foundation
- UC-Irvine College of Health Sciences
- National Heart Lung and Blood Institute [R21 HL104203]
- National Institute for Child Health and Development [R01 HD065536]
- National Institutes of Health Laser Microbeam and Medical Program
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We report a methodology for computing functional vascular density within a rodent dorsal window chamber model based on long-exposure laser speckle imaging (LSI). This technique relies on the presence of flow to create detailed vasculature maps. Employing this contrast mechanism is not possible using conventional imaging methods. Additionally, a freeware algorithm for computing functional vascular density (FVD) from images acquired using long-exposure LSI is also described to facilitate ease in adopting this method. We demonstrate that together these tools can be used to compute RID nearly twelve times faster than manual computation, yet with comparable accuracy. (C) 2011 Elsevier Inc. All rights reserved.
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