Journal
MICROVASCULAR RESEARCH
Volume 75, Issue 2, Pages 135-141Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.mvr.2007.07.004
Keywords
angiogenesis; ischemia; nerve growth factor; tumor growth; wound healing
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Nerve growth factor (NGF), a neurotrophin that plays a crucial role in promoting neurotrophic and neurotropic effects in sympathetic neurons, has recently been identified as a novel angiogenic molecule, which exerts a variety of effects in the cardiovascular system and on endothelial cells. In fact, NGF, may contribute to maintenance, survival, and function of endothelial cells by autocrine and/or paracrine mechanisms. This review summarizes the involvement of NGF in the regulation of angiogenesis in both normal and pathological conditions. (c) 2007 Elsevier Inc. All rights reserved.
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