Journal
SCIENCE
Volume 349, Issue 6252, Pages 1087-1091Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aac6936
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Funding
- Novartis
- NSF through the Materials Research Science and Engineering Center (MRSEC) program
- NSF's MRSEC program [DMR-1121053]
- NIH [1S10OD012077-01A1]
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Most of today's use of transition metal-catalyzed cross-coupling chemistry relies on expensive quantities of palladium (Pd). Here we report that nanoparticles formed from inexpensive FeCl3 that naturally contains parts-per-million (ppm) levels of Pd can catalyze Suzuki-Miyaura reactions, including cases that involve highly challenging reaction partners. Nanomicelles are employed to both solubilize and deliver the reaction partners to the Fe-ppm Pd catalyst, resulting in carbon-carbon bond formation. The newly formed catalyst can be isolated and stored at ambient temperatures. Aqueous reaction mixtures containing both the surfactant and the catalyst can be recycled.
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