Journal
SCHIZOPHRENIA RESEARCH
Volume 161, Issue 2-3, Pages 156-162Publisher
ELSEVIER
DOI: 10.1016/j.schres.2014.10.051
Keywords
Olfactory identification; Olfaction; Smell; At-risk; Ultra-high risk; Psychosis; Schizophrenia; Orbitofrontal cortex; Longitudinal
Categories
Funding
- NHMRC Program [350241, 566529]
- Colonial Foundation, Australia
- National Health and Medical Research Council (NHMRC) Career Development Awards
- Ronald Phillip Griffith Fellowship
- NARSAD Young Investigator Award
- NHMRC Senior Principal and Senior Research Fellowships
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Background: We have previously reported that olfactory identification (OI) deficits are a promising premorbid marker of transition from ultra-high risk (UHR) to schizophrenia, but not to psychotic illness more generally. Whether this remains the case at longer follow-up, and whether there is decline in OI ability are unclear. Method: The University of Pennsylvania Smell Identification Test (UPSIT) was administered to 81 participants at baseline (identification of risk for psychosis) and 254 individuals at follow-up. Forty-nine participants underwent UPSIT assessment at both time points. UPSIT scores were investigated at an average of 7.08 years after identification of risk in relation to transition to psychosis, a diagnosis of schizophrenia, and psychosocial/ functional outcome. Results: UPSIT scores at baseline and follow-up did not differ between participants who transitioned to psychosis and those who did not. Similarly, there were no significant differences on UPSIT scores at baseline or follow-up between individuals with a diagnosis of schizophrenia and transitioned individuals without schizophrenia.Those with a poor functional outcome showed significantly lower baseline UPSIT scores than participants with good outcome. There was no significant association between functional outcome and follow-up UPSIT scores. There were no significant changes in UPSIT over time for any group. Conclusions: These results suggest that impaired OI is not a good marker of the onset of psychosis and schizophrenia, but may differentiate UHR individuals who experience a poor functional outcome, regardless of transition status. (C) 2014 Elsevier B. V. All rights reserved.
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