Journal
MICROPOROUS AND MESOPOROUS MATERIALS
Volume 181, Issue -, Pages 17-22Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.micromeso.2013.07.017
Keywords
Nitric oxide; Diazeniumdiolate; Wound healing; Metal organic framework
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Funding
- R. A. Welch Foundation [A71153]
- Department of Energy, Basic Energy Sciences, Division of Materials Sciences and Engineering [DE-FG02-08ER46491]
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Metal-organic frameworks (MOFs) are generally explored for gas adsorption and separation but more recently they have been studied for use in biomedical applications. The present study focuses on the incorporation of a nitric oxide (NO) donor, called a diazeniumdiolate (NONOate), into a new MOF using a one-step post-synthetic method. The MOF, Cu-TDPAT, contains copper nodes linked by 2,4,6-tris(3,5-dicarboxylphenylamino)-1,3,5-triazine (H(6)TDPAT). This MOF adsorbs NO and the TDPAT linker contains secondary amines which react with NO to form a NONOate. The covalently bound NONOate donor group allows for greater control over the NO storage and delivery rate. Over the course of 7 days, the Cu-TDPAT NONOate will yield approximately 175 mu mol/g NO by exposure to 85% humidity and 53 mu mol/g NO by heating to 37 degrees C. (c) 2013 Elsevier Inc. All rights reserved.
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