Journal
MICROPOROUS AND MESOPOROUS MATERIALS
Volume 142, Issue 1, Pages 194-201Publisher
ELSEVIER
DOI: 10.1016/j.micromeso.2010.11.036
Keywords
Mesoporous material; Silicon; Drug delivery; Magnesiothermic reduction
Categories
Funding
- Outstanding Young Scientist Foundation of NSFC [20625102]
- International Science and Technology Cooperation Program [2007DFA40830]
- NSFC [20831002, 20571030]
- Jilin Province Hi-Tech Development Project [20082104]
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In this study, mesoporous silicon was achieved from ordered mesoporous silica via magnesiothermic reduction reaction, while preserving the original shape, mesoporous structure as well as high surface area. Rod-like SBA-15 with hexagonal array of 2D channels and crystal-like SBA-16 with body centered arrangement of cages were used as precursors, suitable wall thickness and mesoporous structures facilitated the formation of products with high porosity and the preservation of original morphologies. X-ray diffraction (XRD), selected area electron diffraction (SAED), energy dispersive X-ray spectroscopy (EDS) and Raman spectra revealed that high crystallinity and purity of the resulted products were obtained. N-2 sorption isotherm results showed that the mesoporous silicon derived from hexagonal SBA-15 has much higher surface area than that from cubic SBA-16, which is reasonably attributed to the difference of wall thickness and porous structures of the precursors. High surface area Si-SBA-15 was selected as vector and ibuprofen as a model drug for drug release, and the system displayed superior drug loading and good release profile. (C) 2010 Elsevier Inc. All rights reserved.
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