Self-assembly of mesoporous silicas hollow microspheres via food grade emulsifiers for delivery systems

Randomly ordered mesoporous silicas hollow microspheres of 20-50 mu m in diameter with distinguished characteristic of interconnected porosity (7-14 nm) of their thin outer walls are developed. Food grade emulsifier polyglycerol esters of fatty acids (PGEFA) are used as a soft-template and n-decane as a swelling agent, which was necessary for the formation of silica doped micelles to improve the mesoporous channel orientation without leading the phase transition. The interconnected pore channels that extend from the outside of the microspheres shell to its inside are used to fill the mesoporous silicas microspheres for enhanced encapsulation of VB3 precursor and cumulative in vitro release of vitamin B-3 with considerable rate pharmacokinetics using simple pH trigger mechanism for the delivery systems. (C) 2009 Elsevier Inc. All rights reserved.