Journal
MICROPOROUS AND MESOPOROUS MATERIALS
Volume 110, Issue 2-3, Pages 560-569Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.micromeso.2007.06.054
Keywords
functionalized SBA-15; bovine serum albumin; adsorption; release
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Funding
- National Research Foundation of Korea [핵06B1309] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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SBA-15, mesoporous material, is a very excellent candidate for drug delivery system because its pore size is easy to control according to synthesis conditions and the presence of swelling agent. In this study, a known swelling agent, 1,3,5-trimethylbenzene (TMB), was used to increase the pore size with increased aging temperature and prolonged aging time. Furthermore, 3-aminopropyltriethoxysilane (APTES) was incorporated on SBA-15 surface via post synthesis method to separate protein effectively. The samples were characterized by X-ray diffraction (XRD), nitrogen adsorption and desorption analyses, scanning electron microscopy (SEM), transmission electron microscopy (TEM), and Fourier Transform Infrared (FT-IR). Adsorption capacity increased with temperature at the isoelectric point (pI) of bovine serum albumin (BSA) regardless of the pore size of SBA-15 samples. Release studies were carried out in the range of pH from neutral to basic solution on unmodified and amine-modified samples. In addition, the adsorption mechanism was investigated by employing the pseudo-first order, pseudo-second order, and intraparticle diffusion models. (C) 2007 Elsevier Inc. All rights reserved.
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