Journal
MICROPOROUS AND MESOPOROUS MATERIALS
Volume 116, Issue 1-3, Pages 36-43Publisher
ELSEVIER
DOI: 10.1016/j.micromeso.2008.03.012
Keywords
Mesoporous organosilica; trans-(1R,2R)-Diaminocyclohexane; Chiral stationary phase; HPLC; R/S-1,1 '-bi-2-naphthol; Enantiomers separation
Categories
Funding
- National Natural Science Foundation of China [20303020, 20321303, 20503028]
- National Basic Research Program of China [2003 CB 615803]
- Chinese Academy of Sciences [DICP K2003B2, K2006B2]
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New mesoporous organic-inorganic spheres with trans-(1R,2R)-bis-(ureido)-cyclohexane covalently bridged in the pore wall were prepared by co-condensation of N,N'-bis-[(triethoxysilyl)propyl]-trans-(1R,2R)-bis-(ureido)-cyclohexane and 1,2-bis(trimethoxysilyl)ethane through a hierarchical double templating method. The octadecyltrimethylammonium chloride (C(18)TMACI) and ethanol direct the formation of mono-dispersed hybrid spheres. N,N-dimethyldecylamine, acting as a pore expanding agent, can expand the pore diameter of the hybrid material from less than 1.7-10 nm during the post-synthetic treatment process. The hybrid material was employed as a novel kind of chiral stationary phase for high performance liquid chromatography (HPLC. The column packed with the hybrid material with particle size of 6-9 mu m can efficiently separate the R/S-1,1'-bi-2-naphthol enantiomers even at high sample loading and high flow rate because of its high chiral ligand loading (0.93 mmol/g) and high surface area (597 m(2)/g). (C) 2008 Elsevier Inc. All rights reserved.
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