Journal
MICROFLUIDICS AND NANOFLUIDICS
Volume 15, Issue 1, Pages 49-55Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s10404-012-1126-0
Keywords
Microfluidics; Ferrofluid; Particle concentration; Magnetophoresis; Lab on a chip
Funding
- NSF [CBET-1150670]
- Clemson University
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [1150670] Funding Source: National Science Foundation
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Concentrating particles to a detectable level is often necessary in many applications. Although magnetic force has long been used to enrich magnetic (or magnetically tagged) particles in suspensions, magnetic concentration of diamagnetic particles is relatively new and little reported. We demonstrate in this work a simple magnetic technique to concentrate polystyrene particles and live yeast cells in ferrofluid flow through a straight rectangular microchannel using negative magnetophoresis. The magnetic field gradient is created by two attracting permanent magnets that are placed on the top and bottom of the planar microfluidic device and held in position by their natural attractive force. The magnet-magnet distance is mainly controlled by the thickness of the device substrate and can be made small, allowing for the use of a dilute ferrofluid in the developed magnetic concentration technique. This advantage not only enables a magnetic/fluorescent label-free handling of diamagnetic particles, but also renders such handling biocompatible.
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