Journal
MICROELECTRONIC ENGINEERING
Volume 88, Issue 8, Pages 1718-1721Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.mee.2010.12.054
Keywords
Polymer fibers; Scaffolds; Cell culture; Tissue engineering
Categories
Funding
- Japanese Government [22710116, 22350104]
- European Commission [CP-FP 214566-2]
- Grants-in-Aid for Scientific Research [22350104, 22710116] Funding Source: KAKEN
Ask authors/readers for more resources
We demonstrate a mass production amenable technology for the fabrication of polymer fibers that can be used as 3D scaffolds for cell culture and tissue engineering. As the first attempt, we used centrifugal melt spinning technique to fabricate fiber matrix of poly-lactic-co-glycolic acid (PLGA) which is a well-known biodegradable co-polymer. We then developed a solvent assisted centrifugal spinning technique to produce fiber matrix of polystyrene (PS) which has a relative high glass transition temperature comparing to that of PLGA. Both melt spinning and solvent assisted spinning techniques were studied with two types of commercial cotton-candy machines. Finally, the fabricated fibers were used as scaffolds for cell culture, showing application potentials for large volume cell proliferation. (C) 2010 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available