Fabrication of BioFET linear array for detection of protein interactions

An extended-gate MOSFETs (metal-oxide-semiconductor field-effect transistors) based biosensing linear array has been fabricated for label-free protein interaction detection. The device was realized using a combination of very low leakage current MOSFET transistors and an external gate where the chemical reaction would take place. Peptide aptamers that recognize cyclin-dependent kinase (CDK), a protein cancer marker, were used as a biological test system. The test results showed a high sensitive in the detection of CDK. (C) 2009 Elsevier B.V. All rights reserved.