Journal
MICROCIRCULATION
Volume 16, Issue 4, Pages 307-322Publisher
WILEY
DOI: 10.1080/10739680902744404
Keywords
myoendothelial junction; microdomain; gap junction; heterocellular signaling; endothelium; smooth muscle
Categories
Funding
- NIH [HL088554]
- American Heart Association Scientist Development
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL088554] Funding Source: NIH RePORTER
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Within the vasculature, specialized cellular extensions from endothelium (and sometimes smooth muscle) protrude through the extracellular matrix where they interact with the opposing cell type. These structures, termed myoendothelial junctions, have been cited as a possible key element in the control of several vascular physiologies and pathologies. This review will discuss observations that have led to a focus on the myoendothelial junction as a cellular integration point in the vasculature for both homeostatic and pathological conditions and as a possible independent signaling entity. We will also highlight the need for novel approaches to studying the myoendothelial junction in order to comprehend the cellular biology associated with this structure.
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