Journal
MICROCHIMICA ACTA
Volume 181, Issue 13-14, Pages 1485-1495Publisher
SPRINGER WIEN
DOI: 10.1007/s00604-014-1204-y
Keywords
Near-infrared quantum dots; Bioanalytical application; review
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Funding
- National Natural Science Foundation of China [21175051, 21375043, 21305049]
- Fundamental Research Funds for the Central Universities [2010PY009, 2010PY139, 2010YB03]
- Natural Science Foundation of Hubei Province Innovation Team [2011CDA115]
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Near-infrared quantum dots (NIR QDs) represent a powerful material and diagnostic tool owing to their long emission wavelength which extends into the near-infrared region where permeation depths are much larger and where the intrinsic absorbance and autofluorescence of tissue is much smaller compared to shortwave emitting QDs. We are reviewing here recent (2008-2013) methods for the preparation of NIR QDs, their (bio) chemical modifications, and their applications. The article is subdivided into the following sections: (a) Synthesis of NIR QDs; (b) modification of NIR QDs and probe preparation; (c) applications of NIR QDs (with subsections on fluorescence quenching and fluorescence enhancement-based bioanalytical detection, on fluorescence bioimaging, on uses in photovoltaic cells and solar cells, and on molecular detection based on electrogenerated chemiluminescence). We finally make conclusions and discuss current challenges, trends, and future applications. The review contains 119 references.
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