Journal
MICROCHIMICA ACTA
Volume 180, Issue 9-10, Pages 903-910Publisher
SPRINGER WIEN
DOI: 10.1007/s00604-013-1011-x
Keywords
4-Sulfa-6-Chloropyrimidine; Fragment-Imprinted Microspheres; Suspension Polymerization; Sulfonamides
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Funding
- Key Scientific and Technological Project of Henan Province [112102310030]
- Natural Science Basic Research Plan in the Education Department of Henan Province [2010A150006]
- Plan of Nature Science Fundamental Research in Henan University of Technology
- Education Innovation Foundation for the Postgraduate of Henan University of Technology [11YJCX08]
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Fragment-imprinted microspheres (FIMs) were synthesized by suspension polymerization of 4-sulfa-6-chloropyrimidine (the template), methacrylic acid and styrene (the mixed functional monomers), divinylbenzene (the crosslinker), and azobisisobutyronitrile (the initiator). The optimum conditions were obtained by an orthogonal experiment. After removal of the templates, the microspheres serve as a material to fairly specifically bind sulfonamides, the absorption capacity being 6.32 mg g(-1), whereas the absorption by non-imprinted microspheres is 1.68 mg g(-1). A method was worked out for the simultaneous determination of five sulfonamides by solid phase extraction (using the FIMs) coupled to HPLC, and applied to analyze milk samples. The recoveries are within 87.6 and 96.5 %, with relative standard deviations between 1.25 and 2.89 %.
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