Journal
MICROCHIMICA ACTA
Volume 180, Issue 1-2, Pages 33-39Publisher
SPRINGER WIEN
DOI: 10.1007/s00604-012-0897-z
Keywords
Molecularly imprinted polymer; Electrochemical sensor; Ortho-phenylenediamine; Lorazepam
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Funding
- research Affairs Division
- Research Council of Isfahan University of Technology (IUT)
- Center of Excellency in Sensor and Green Chemistry
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We report on an electrode for the amperometric determination of lorazepam. A glassy carbon electrode was coated with a molecular imprint made by electropolymerization of ortho-phenylenediamine and filled with multi-walled carbon nanotubes and gold nanoparticles, which enhances the transmission of electrons. The sensor was studied with respect to its response to hexacyanoferrate (III) as a probe and by electrochemical impedance spectroscopy, cyclic voltammetry and square wave voltammetry. The linear response range to Lorazepam is from 0.5 nM to 1.0 nM and from 1.0 nM to 10.0 nM, with a detection limit of 0.2 nM (at an S/N of 3). The electrode was successfully applied to determine Lorazepam in spiked human serum.
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