Journal
MICROCHIMICA ACTA
Volume 175, Issue 1-2, Pages 39-46Publisher
SPRINGER WIEN
DOI: 10.1007/s00604-011-0652-x
Keywords
Paracetamol; Layered double hydroxide; Gold nanoparticles; Anionic surfactant; Electrochemical determination
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Funding
- National Natural Science Foundation of China [21075078]
- Natural Science Foundation of Shandong province, China [ZR2010BM005]
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A differential pulse voltammetric method was developed for the simultaneous determination of paracetamol, 4-aminophenol and dopamine at pH 7.0 using a glassy carbon electrode (GCE) coated with gold nanoparticles (AuNPs) and a layered double hydroxide sodium modified with dodecyl sulfate (SDS-LDH). The modified electrode displays excellent redox activity towards paracetamol, and the redox current is increased (and the corresponding over-potential decreased) compared to those of the bare GCE, the AuNPs-modified GCE, and the SDS-LDH-modified GCE. The modified electrode enables the determination of paracetamol in the concentration range from 0.5 to 400 mu M, with a detection limit of 0.13 mu M (at an S/N of 3). The sensor was successfully applied to the stimultaneous determination of paracetamol and dopamine, and of paracetamol and 4-aminophenol, respectively, in pharmaceutical tablets and in spiked human serum samples.
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