Journal
MICROCHIMICA ACTA
Volume 173, Issue 1-2, Pages 149-156Publisher
SPRINGER WIEN
DOI: 10.1007/s00604-010-0537-4
Keywords
Au/Ag core-shell nanostructures; Surface enhanced Raman scattering; Biosensing; Immunoassay; Muramidase released protein
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Funding
- National Natural Science Foundation of China [20975042]
- Program for academic pacesetter of Wuhan [200851430484]
- Nature Science foundation key project from Hubei Province of China [2008CDA080]
- International Science and Technology cooperation and Exchange Foundation [2008DFA40270]
- Fundamental Research Funds for the Central Universities of China [2009JC005]
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We describe a novel surface-enhanced Raman scattering (SERS) tag that is based on Au/Ag core-shell nanostructures embedded with p-aminothiophenol. The Au/Ag core-shell sandwich nanostructures demonstrate bright and dark stripe structure and possess very strong SERS activity. Under optimum conditions, the maximum SERS signal was obtained with a 10 nm thick Ag nanoshell, and the enhancement factor is 3.4 x 10(4) at 1077 cm(-1). After conjugation to the antibody of muramidase releasing protein (MRP), the Au/Ag core-shell nanostructures were successfully applied to an SERS-based detection scheme for MRP based on a sandwich type of immunoassay.
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