Novel glucose biosensor based on a glassy carbon electrode modified with hollow gold nanoparticles and glucose oxidase

A novel glucose biosensor is presented as that based on a glassy carbon electrode modified with hollow gold nanoparticles (HGNs) and glucose oxidase. The sensor exhibits a better differential pulse voltammetric response towards glucose than the one based on conventional gold nanoparticles of the same size. This is attributed to the good biological conductivity and biocompatibility of HGNs. Under the optimal conditions, the sensor displays a linear range from 2.0 x 10(-6) to 4.6 x 10(-5) M of glucose, with a detection limit of 1.6 x 10(-6) M (S/N = 3). Good reproducibility, stability and no interference make this biosensor applicable to the determination of glucose in samples such as sports drinks.