Journal
MICROCHIMICA ACTA
Volume 169, Issue 1-2, Pages 33-40Publisher
SPRINGER WIEN
DOI: 10.1007/s00604-010-0307-3
Keywords
Multiwalled carbon nanotubes; Carboxylation; Modified electrode; Guanine and adenine; Calf thymus dsDNA
Categories
Funding
- National Outstanding Youth Foundations of China [50725825]
- National Natural Science Foundation of China [50908113, 20765003]
- Natural Science Foundation of Jiangxi Province [2008GZH0008]
- Youth Foundation of Jiangxi Provincial Department of Education [GJJ09483]
- Opening Fund of the Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education of China)
- Hunan Normal University [KLCBTCMR2008-08]
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A method is presented for the carboxylation of multiwalled carbon nanotubes (MWCNTs) via a two-step process. The hydroxy groups of MWCNTs were first reacted with epichlorohydrin, then with iminodiacetic acid. The resulting MWCNTs were characterized by means of Fourier transform infrared spectroscopy and transmission electron microscopy. The glassy carbon electrode modified with the MWCNTs thus prepared exhibited enhanced electrocatalytic activity and good stability for the determination of guanine and adenine in pH 7.0 phosphate buffer solution. The experimental parameters were optimized, and a direct electrochemical method was developed for the simultaneous determination of guanine and adenine. The detection limits (at S/N = 3) for guanine and adenine are 0.02 and 0.08 mu M, respectively. A sensitive method was also developed for the determination of guanine and adenine in calf thymus DNA.
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