Journal
MICROCHIMICA ACTA
Volume 172, Issue 1-2, Pages 15-23Publisher
SPRINGER WIEN
DOI: 10.1007/s00604-010-0464-4
Keywords
Norfloxacin; Molecularly-imprinted sensors; Potentiometry; FIA; Fish
Categories
Funding
- FCT, Fundacao para a Ciencia e Tecnologia
- FEDER [PTDC/AGR-AAM/68359/2006]
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A biomimetic sensor for norfloxacin is presented that is based on host-guest interactions and potentiometric transduction. The artificial host was imprinted into polymers made from methacrylic acid and/or 2-vinyl pyridine. The resulting particles were entrapped in a plasticized poly(vinyl chloride) (PVC) matrix. The sensors exhibit near-Nernstian response in steady state evaluations, and detection limits range from 0.40 to 1.0 mu g mL(-1), respectively, and are independent of pH values at between 2 and 6, and 8 and 11, respectively. Good selectivity was observed over several potential interferents. In flowing media, the sensors exhibit fast response, a sensitivity of 68.2 mV per decade, a linear range from 79 mu M to 2.5 mM, a detection limit of 20 mu g mL(-1), and a stable baseline. The sensors were successfully applied to field monitoring of norfloxacin in fish samples, biological samples, and pharmaceutical products. vertical bar
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