A highly sensitive method for determination of paracetamol by adsorptive stripping voltammetry using a carbon paste electrode modified with nanogold and glutamic acid

A reliable and simple sensor was fabricated by modifying a carbon paste electrode with nanosized gold particles and poly (glutamic acid) for determination of paracetamol (PAR). The modified electrode exhibited an effective catalytic response to the oxidation and reduction of PAR with good reproducibility and stability. The determination was carried out by differential pulse adsorptive stripping voltammetry after a 30 s accumulation time with an open circuit potential and under stirring. The calibration curve is linear in the range from 0.05 to 70 mu M of PAR (with a correlation coefficient of 0.9990), and the sensitivity is 1.51 mu A.mu M-1. The modified electrode was used to detect PAR in commercial tablets.