Journal
MICROBIOLOGY-SGM
Volume 158, Issue -, Pages 1057-1070Publisher
MICROBIOLOGY SOC
DOI: 10.1099/mic.0.056127-0
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Funding
- European Commission [MTKD-CT-2006-042062, O36341]
- Science Foundation of Ireland (SFI) [02/IN.I/B1261, 04/BR/B0597]
- Department of Agriculture and Food [DAF RSF 06 321, DAF RSF 06 377]
- Irish Research Council for Science, Engineering and Technology (IRCSET) [05/EDIV/FP107]
- Health Research Board [RP/2004/145, RP/2006/271, RP/2007/290]
- Environmental Protection Agency (EPA) [2006-PhD-S-21]
- Higher Education Authority of Ireland [PRTLI3]
- SFI Centres for Science Engineering and Technology (CSET)
- Environmental Protection Agency Ireland (EPA) [2006-PhD-S-21] Funding Source: Environmental Protection Agency Ireland (EPA)
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Sensitive sensory mechanisms are instrumental in affording Pseudomonas aeruginosa the capacity to establish diverse yet severe human infections, which can manifest themselves in long-term untreatable disease. The ability of P. aeruginosa to tightly regulate gene expression and virulence factor production, in response to activation of these sensory components, enables the pathogen to sustain infection despite the host immune response and aggressive antibiotic treatment. Although a number of factors are recognized as playing a role in early infection, very little is known regarding the sensors involved in this process. In this study, we identified P. aeruginosa PA3191 as a novel host-responsive sensor that plays a key role during P. aeruginosa-host interactions and is required for optimum colonization and dissemination in a mouse model of infection. We demonstrated that PA3191 contributed to modulation of the type III secretion system (T3SS) in response to host cells and T3SS-inducing conditions in vitro. PA3191 (designated GtrS) acted in concert with the response regulator GltR to regulate the OprB transport system and subsequently carbon metabolism. Through this signal transduction pathway, T3SS activation was mediated via the RsmAYZ regulatory cascade and involved the global anaerobic response regulator Anr.
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