Journal
MICROBIOLOGY AND IMMUNOLOGY
Volume 57, Issue 10, Pages 732-735Publisher
WILEY
DOI: 10.1111/1348-0421.12082
Keywords
mini-host models; pythiosis; Toll receptors
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Funding
- MD Anderson Cancer Center core grant [CA 16672]
- National Council of Scientific and Technological Development (CNPq-Brazil)
- PNPD-CAPES fellowship
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There is a paucity of animal models of pythiosis, a life-threatening disease of humans and animals, the immunopathogenesis of which is poorly understood. A pythiosis model was developed by injecting Toll (Tl)-deficient Drosophila melanogaster flies with Pythium insidiosum zoospores. The infected Tl mutant flies had significantly lower survival rates (73.7%) than did control flies. This study reveals the important role of Tl pathway activation in fly immune response to pythiosis.
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